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KMID : 0379520030190020147
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한국독성학회지
2003 Volume.19 No. 2 p.147 ~ p.152
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Antitumor Activities to Cytotoxicity of Phellinus linteus Ethanol Extract
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Han Ki-Won
Lee Soo-Won
Han Koang-Soo
Lee Dae-Jin
Lee Byung-Eui
Jang Won-Choeul
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Abstract
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We investigated antitumor activities of the ethanol extract from mushroom Phellinus linteus and Phellinus baumii on mulberry, oak and elm. in vitro test, the ethanol extract of mushroom cultivated on oak of Phellinus linteus showed highest activities about SK-OV-3, HCT15, XF498, SK-MEL-2 and A549. SK-OV-3 cell line showed 100% cytotoxicity in 100 mutextrm{g}/ml and HCT15 (98.39%), XF498 (89.62%), SK-MEL-2 (84.07%) and A549 (79.92%) cytotoxicity respectively. Also IC_{50} showed 3.99 mutextrm{g}/ml to SK-OV-3 cell line and HCT15 (4.37 mutextrm{g}/ml), A549 (5.48 mutextrm{g}/ml), SK-MEL-2 (6.72 mutextrm{g}/ml), XF 498 (6.88 mutextrm{g}/ml). As those results, cultivated oak of Phellinus linteus showed a very low IC_{50} value against SK-OV-3, HCT15, XF498, SK-MEL-2 and A549 cancer cell lines.
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KEYWORD
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Phellinus linteus, Phellinus baumii, Cytotoxicity
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